Question 1: Which of the following cells in the human body exhibit amoeboid movement?
- a) Macrophages and leucocytes.
- b) Erythrocytes and lymphocytes.
- c) Macrophages and fibroblasts.
- d) Hepatocytes and leucocytes.
Answer: a.
Question 2: The coordinated movement of cilia in the trachea assists in which of the following processes?
- a) Pushing the ovum through the fallopian tube.
- b) Removing dust particles and foreign substances inhaled along with atmospheric air.
- c) Facilitating the movement of food through the oesophagus.
- d) Enhancing the absorption of nutrients in the small intestine.
Answer: b.
Question 3: About what percentage of the body weight of a human adult is contributed by muscles?
- a) 20-30 percent.
- b) 30-40 percent.
- c) 40-50 percent.
- d) 50-60 percent.
Answer: c.
Question 4: Which of the following properties is exclusively associated with muscle tissue?
- a) Excitability and conductivity.
- b) Contractility and extensibility.
- c) Elasticity and secretion.
- d) Excitability, contractility, extensibility and elasticity.
Answer: d.
Question 5: Visceral muscles are primarily located in the inner walls of which of the following structures?
- a) Heart and blood vessels.
- b) Alimentary canal and reproductive tract.
- c) Lungs and diaphragm.
- d) Skeletal bones and skin.
Answer: b.
Question 6: Cardiac muscles are anatomically distinct from skeletal muscles because they are:
- a) Striated and involuntary.
- b) Unstriated and involuntary.
- c) Striated and voluntary.
- d) Unstriated and voluntary.
Answer: a.
Question 7: A collagenous connective tissue layer that holds together multiple muscle bundles (fascicles) is known as:
- a) Epimysium.
- b) Endomysium.
- c) Fascia.
- d) Perimysium.
Answer: c.
Question 8: The plasma membrane enclosing the muscle fibre is specifically termed as:
- a) Sarcoplasm.
- b) Sarcolemma.
- c) Sarcoplasmic reticulum.
- d) Endoplasmic reticulum.
Answer: b.
Question 9: The sarcoplasmic reticulum of muscle fibres serves as a major storehouse for which of the following ions?
- a) Sodium ions.
- b) Potassium ions.
- c) Calcium ions.
- d) Magnesium ions.
Answer: c.
Question 10: The characteristic striated appearance of a skeletal muscle fibre is due to the distribution pattern of:
- a) Actin and myosin proteins.
- b) Troponin and tropomyosin proteins.
- c) Myoglobin and hemoglobin.
- d) Collagen and elastin.
Answer: a.
Question 11: The light bands in a myofibril contain primarily which protein and are known as?
- a) Myosin, A-band.
- b) Actin, I-band.
- c) Actin, A-band.
- d) Myosin, I-band.
Answer: b.
Question 12: An elastic fibre called the 'Z' line bisects which of the following bands?
- a) A-band.
- b) I-band.
- c) H-zone.
- d) M-line.
Answer: b.
Question 13: The functional unit of contraction in a muscle fibre is defined as the portion of the myofibril between two successive:
- a) M-lines.
- b) Z-lines.
- c) A-bands.
- d) I-bands.
Answer: b.
Question 14: In a resting state, the central part of the thick filament that is not overlapped by thin filaments is called the:
- a) Z-line.
- b) M-line.
- c) H-zone.
- d) I-band.
Answer: c.
Question 15: Each actin (thin) filament is composed of how many 'F' (filamentous) actin helically wound to each other?
- a) One.
- b) Two.
- c) Three.
- d) Four.
Answer: b.
Question 16: Troponin is a complex protein distributed at regular intervals on which of the following proteins?
- a) F-actin.
- b) Tropomyosin.
- c) Myosin.
- d) Meromyosin.
Answer: b.
Question 17: In the resting state, troponin masks the active binding sites for which protein?
- a) Actin on the myosin filaments.
- b) Myosin on the actin filaments.
- c) Calcium on the sarcoplasmic reticulum.
- d) ATP on the myosin head.
Answer: b.
Question 18: Each myosin filament is a polymerized protein consisting of many monomeric proteins called:
- a) G-actins.
- b) F-actins.
- c) Meromyosins.
- d) Tropomyosins.
Answer: c.
Question 19: The globular head of a meromyosin molecule functions as an active ATPase enzyme and has binding sites for:
- a) Actin and Tropomyosin.
- b) ATP and Troponin.
- c) ATP and active sites for actin.
- d) Calcium and ATP.
Answer: c.
Question 20: Heavy Meromyosin (HMM) consists of which components of the meromyosin molecule?
- a) Globular head and short arm.
- b) Tail and short arm.
- c) Globular head and tail.
- d) Tail only.
Answer: a.
Question 21: The mechanism of muscle contraction is best explained by the sliding filament theory, which states that:
- a) Thick filaments slide over thin filaments.
- b) Thin filaments slide over thick filaments.
- c) Both thick and thin filaments contract in length.
- d) Z-lines are stretched outwards.
Answer: b.
Question 22: The neuromuscular junction is a synapse between a motor neuron and which of the following?
- a) Muscle fascicle.
- b) Sarcolemma of the muscle fibre.
- c) Sarcoplasmic reticulum.
- d) Myofibril.
Answer: b.
Question 23: When a neural signal reaches the neuromuscular junction, it releases a neurotransmitter. Identify the correct neurotransmitter.
- a) Dopamine.
- b) Serotonin.
- c) Acetylcholine.
- d) GABA.
Answer: c.
Question 24: The generation of an action potential in the sarcolemma leads to the release of calcium ions into the:
- a) Extracellular fluid.
- b) Sarcoplasmic reticulum.
- c) Sarcoplasm.
- d) T-tubules.
Answer: c.
Question 25: Increased calcium levels in the sarcoplasm lead to the binding of calcium with a subunit of which protein?
- a) Tropomyosin.
- b) Troponin.
- c) Actin.
- d) Myosin.
Answer: b.
Question 26: The formation of a cross-bridge during muscle contraction requires energy obtained from the hydrolysis of:
- a) GTP.
- b) ADP.
- c) ATP.
- d) AMP.
Answer: c.
Question 27: During muscle contraction, the sliding of the thin filaments pulls the Z-lines attached to them inwards, resulting in:
- a) Lengthening of the sarcomere.
- b) Shortening of the sarcomere.
- c) Disappearance of the A-band.
- d) Widening of the H-zone.
Answer: b.
Question 28: What happens to the A-band and I-band during the shortening of the muscle?
- a) Both A-band and I-band retain their length.
- b) A-band shortens while I-band retains its length.
- c) I-band shortens while A-band retains its length.
- d) Both A-band and I-band shorten.
Answer: c.
Question 29: The cross-bridge is broken when the myosin head binds to which newly available molecule?
- a) Calcium.
- b) ADP.
- c) ATP.
- d) Inorganic phosphate.
Answer: c.
Question 30: Repeated activation of muscles can lead to fatigue due to the anaerobic breakdown of glycogen into:
- a) Pyruvic acid.
- b) Lactic acid.
- c) Carbon dioxide and water.
- d) Ethanol.
Answer: b.
Question 31: Red muscle fibres appear reddish due to the high content of which oxygen-storing pigment?
- a) Hemoglobin.
- b) Myoglobin.
- c) Cytochrome.
- d) Chlorocruorin.
Answer: b.
Question 32: White muscle fibres are characterized by having:
- a) High myoglobin and high mitochondria.
- b) Low myoglobin and high mitochondria.
- c) Low myoglobin and high sarcoplasmic reticulum.
- d) High myoglobin and high sarcoplasmic reticulum.
Answer: c.
Question 33: Red muscle fibres can also be called aerobic muscles because they utilise a large amount of oxygen stored within them for:
- a) Lactic acid fermentation.
- b) ATP production.
- c) Glycogenesis.
- d) Gluconeogenesis.
Answer: b.
Question 34: The skeletal system is composed of a framework of bones and a few cartilages. How many bones are present in an adult human?
- a) 300.
- b) 206.
- c) 256.
- d) 200.
Answer: b.
Question 35: Bone has a very hard matrix due to the presence of:
- a) Chondroitin salts.
- b) Calcium salts.
- c) Sodium chloride.
- d) Potassium phosphate.
Answer: b.
Question 36: Cartilage has a slightly pliable matrix due to the presence of:
- a) Calcium salts.
- b) Chondroitin salts.
- c) Keratin sulfate.
- d) Hyaluronic acid.
Answer: b.
Question 37: The axial skeleton comprises how many bones distributed along the main axis of the body?
- a) 126.
- b) 80.
- c) 60.
- d) 100.
Answer: b.
Question 38: The skull is composed of two sets of bones: cranial and facial. What is the total number of bones in the human skull (excluding ear ossicles and hyoid)?
- a) 14.
- b) 8.
- c) 22.
- d) 29.
Answer: c.
Question 39: How many cranial bones form the hard protective outer covering for the brain?
- a) 8.
- b) 12.
- c) 14.
- d) 22.
Answer: a.
Question 40: The facial region is made up of how many skeletal elements that form the front part of the skull?
- a) 8.
- b) 12.
- c) 14.
- d) 22.
Answer: c.
Question 41: A single U-shaped bone present at the base of the buccal cavity is called:
- a) Mandible.
- b) Maxilla.
- c) Hyoid.
- d) Palatine.
Answer: c.
Question 42: Each middle ear contains three tiny bones collectively known as ear ossicles. Which of the following is NOT one of them?
- a) Malleus.
- b) Incus.
- c) Stapes.
- d) Sphenoid.
Answer: d.
Question 43: The human skull articulates with the superior region of the vertebral column with the help of how many occipital condyles?
- a) One.
- b) Two.
- c) Three.
- d) Four.
Answer: b.
Question 44: The vertebral column is formed by serially arranged units called vertebrae. How many vertebrae are present in an adult human?
- a) 24.
- b) 26.
- c) 31.
- d) 33.
Answer: b.
Question 45: The first vertebra, which articulates with the occipital condyles, is known as:
- a) Axis.
- b) Atlas.
- c) Cervical vertebra 3.
- d) Thoracic vertebra 1.
Answer: b.
Question 46: The typical vertebral formula for the cervical, thoracic, lumbar, sacral, and coccygeal regions in a human adult is:
- a) C7, T12, L5, S1, Co1.
- b) C7, T10, L5, S5, Co4.
- c) C8, T12, L5, S1, Co1.
- d) C7, T12, L4, S1, Co2.
Answer: a.
Question 47: The central hollow portion of a vertebra through which the spinal cord passes is called the:
- a) Neural canal.
- b) Intervertebral disc.
- c) Transverse foramen.
- d) Vertebral foramen.
Answer: a.
Question 48: Which bone serves as a flat bone on the ventral midline of the thorax?
- a) Clavicle.
- b) Scapula.
- c) Sternum.
- d) Rib.
Answer: c.
Question 49: How many pairs of ribs are present in the human body?
- a) 10.
- b) 12.
- c) 14.
- d) 24.
Answer: b.
Question 50: True ribs are attached dorsally to the thoracic vertebrae and ventrally to the sternum with the help of:
- a) Fibrocartilage.
- b) Elastic cartilage.
- c) Hyaline cartilage.
- d) Calcified cartilage.
Answer: c.
Question 51: Which pairs of ribs are known as vertebrochondral or false ribs?
- a) 1st to 7th.
- b) 8th, 9th, and 10th.
- c) 11th and 12th.
- d) 7th, 8th, and 9th.
Answer: b.
Question 52: The floating ribs are named so because they are not connected ventrally. Which pairs correspond to floating ribs?
- a) 9th and 10th.
- b) 10th and 11th.
- c) 11th and 12th.
- d) 8th and 9th.
Answer: c.
Question 53: The rib cage is formed by the association of which of the following skeletal structures?
- a) Thoracic vertebrae, ribs, and sternum.
- b) Cervical vertebrae, ribs, and sternum.
- c) Lumbar vertebrae, ribs, and sternum.
- d) Thoracic vertebrae, clavicle, and sternum.
Answer: a.
Question 54: The appendicular skeleton includes the bones of the limbs along with their respective girdles. How many bones are present in each limb?
- a) 20.
- b) 30.
- c) 40.
- d) 60.
Answer: b.
Question 55: The longest bone in the human body is present in the hindlimb and is called the:
- a) Tibia.
- b) Fibula.
- c) Femur.
- d) Humerus.
Answer: c.
Question 56: The bones of the forelimb include all of the following EXCEPT:
- a) Humerus.
- b) Radius and Ulna.
- c) Carpals and Metacarpals.
- d) Tarsals and Metatarsals.
Answer: d.
Question 57: How many carpal bones (wrist bones) are present in each human forelimb?
- a) 5.
- b) 7.
- c) 8.
- d) 14.
Answer: c.
Question 58: The phalangeal formula for the human hand (fingers) is:
- a) 2, 3, 3, 3, 3.
- b) 3, 3, 3, 3, 3.
- c) 2, 2, 3, 3, 3.
- d) 3, 2, 3, 3, 3.
Answer: a.
Question 59: A cup-shaped bone that covers the knee ventrally is called the:
- a) Patella.
- b) Calcaneus.
- c) Talus.
- d) Navicular.
Answer: a.
Question 60: The tarsals (ankle bones) in each hindlimb amount to a total number of:
- a) 5.
- b) 7.
- c) 8.
- d) 14.
Answer: b.
Question 61: The pectoral girdle is composed of two halves, each containing which two bones?
- a) Ilium and Ischium.
- b) Scapula and Clavicle.
- c) Radius and Ulna.
- d) Sternum and Scapula.
Answer: b.
Question 62: The scapula is a large triangular flat bone situated in the dorsal part of the thorax between the levels of the:
- a) 1st and 5th ribs.
- b) 2nd and 7th ribs.
- c) 3rd and 8th ribs.
- d) 4th and 9th ribs.
Answer: b.
Question 63: The elevated ridge on the scapula is known as the spine, which projects as a flat, expanded process called the:
- a) Coracoid process.
- b) Acromion.
- c) Glenoid cavity.
- d) Olecranon process.
Answer: b.
Question 64: The depression below the acromion that articulates with the head of the humerus to form the shoulder joint is the:
- a) Acetabulum.
- b) Glenoid cavity.
- c) Obturator foramen.
- d) Symphysis pubis.
Answer: b.
Question 65: Each clavicle is a long slender bone with two curvatures, commonly referred to as the:
- a) Shoulder blade.
- b) Collar bone.
- c) Breast bone.
- d) Thigh bone.
Answer: b.
Question 66: The pelvic girdle consists of two coxal bones. Each coxal bone is formed by the fusion of three bones named:
- a) Ilium, ischium, and pubis.
- b) Scapula, clavicle, and sternum.
- c) Maxilla, mandible, and palatine.
- d) Talus, calcaneus, and cuboid.
Answer: a.
Question 67: At the point of fusion of the ilium, ischium, and pubis, a cavity is formed to which the thigh bone articulates. This cavity is the:
- a) Glenoid cavity.
- b) Acetabulum.
- c) Pelvic inlet.
- d) Greater sciatic notch.
Answer: b.
Question 68: The two halves of the pelvic girdle meet ventrally to form the pubic symphysis, which contains:
- a) Hyaline cartilage.
- b) Elastic cartilage.
- c) Fibrous cartilage.
- d) Synovial fluid.
Answer: c.
Question 69: Joints are points of contact between bones or between bones and cartilages. They are classified into three major structural forms. Which is NOT one of them?
- a) Fibrous joints.
- b) Cartilaginous joints.
- c) Synovial joints.
- d) Muscular joints.
Answer: d.
Question 70: Fibrous joints do not allow any movement. These joints are prominently seen in the:
- a) Knee joint.
- b) Flat skull bones fusing to form the cranium.
- c) Joint between adjacent vertebrae.
- d) Shoulder joint.
Answer: b.
Question 71: The sutures in the skull are an example of which type of joint?
- a) Synovial joint.
- b) Cartilaginous joint.
- c) Fibrous joint.
- d) Gliding joint.
Answer: c.
Question 72: In cartilaginous joints, the bones involved are joined together with the help of cartilages. This joint permits:
- a) No movement.
- b) Limited movement.
- c) Considerable movement.
- d) Free movement in all directions.
Answer: b.
Question 73: The joint between the adjacent vertebrae in the vertebral column is an example of a:
- a) Synovial joint.
- b) Fibrous joint.
- c) Cartilaginous joint.
- d) Pivot joint.
Answer: c.
Question 74: Synovial joints are characterized by the presence of a fluid-filled synovial cavity between the articulating surfaces. This allows for:
- a) Zero movement.
- b) Limited movement.
- c) Considerable movement.
- d) Fusion of bones over time.
Answer: c.
Question 75: The joint between the humerus and the pectoral girdle is an example of a:
- a) Hinge joint.
- b) Pivot joint.
- c) Ball and socket joint.
- d) Saddle joint.
Answer: c.
Question 76: The knee joint is an example of which type of synovial joint?
- a) Ball and socket joint.
- b) Hinge joint.
- c) Gliding joint.
- d) Pivot joint.
Answer: b.
Question 77: The joint between the atlas and axis vertebrae permits rotational movement and is classified as a:
- a) Gliding joint.
- b) Saddle joint.
- c) Pivot joint.
- d) Fibrous joint.
Answer: c.
Question 78: The joint between the carpals is uniquely characterized as a:
- a) Pivot joint.
- b) Gliding joint.
- c) Hinge joint.
- d) Saddle joint.
Answer: b.
Question 79: The joint between the carpal and metacarpal of the human thumb allows for specialized movements and is called a:
- a) Saddle joint.
- b) Gliding joint.
- c) Hinge joint.
- d) Ball and socket joint.
Answer: a.
Question 80: Myasthenia gravis is an autoimmune disorder primarily affecting the:
- a) Central nervous system.
- b) Neuromuscular junction.
- c) Sarcoplasmic reticulum.
- d) Synovial joints.
Answer: b.
Question 81: The pathogenesis of Myasthenia gravis leads to which of the following classical symptoms?
- a) Rapid spasms and wild tetanic contractions.
- b) Inflammation of joints due to uric acid accumulation.
- c) Fatigue, weakening, and paralysis of skeletal muscle.
- d) Progressive degeneration of smooth muscles.
Answer: c.
Question 82: Muscular dystrophy is a genetic disorder characterized by the progressive degeneration of:
- a) Cardiac muscle.
- b) Skeletal muscle.
- c) Visceral muscle.
- d) Motor neurons.
Answer: b.
Question 83: Tetany refers to rapid spasms (wild contractions) in muscle tissues caused primarily by:
- a) Low calcium levels in body fluid.
- b) High calcium levels in body fluid.
- c) Accumulation of lactic acid in muscles.
- d) Breakdown of the neuromuscular junction.
Answer: a.
Question 84: Arthritis is a general medical term defined as the:
- a) Progressive degeneration of skeletal muscles.
- b) Inflammation of joints.
- c) Autoimmune destruction of the neuromuscular junction.
- d) Decreased bone mass.
Answer: b.
Question 85: Osteoporosis is an age-related disorder characterized by decreased bone mass and increased chances of fractures. A common cause of this in females is:
- a) Increased levels of estrogen.
- b) Decreased levels of estrogen.
- c) Accumulation of uric acid.
- d) Excessive muscle contraction.
Answer: b.
Question 86: Gout is an inflammatory joint condition caused by the accumulation of:
- a) Calcium carbonate crystals.
- b) Uric acid crystals.
- c) Lactic acid crystals.
- d) Chondroitin sulfate.
Answer: b.
Question 87: Assertion (A): In a resting muscle fibre, the H-zone is clearly visible. Reason (R): The H-zone is the central gap between the ends of thin filaments overlapping the thick filaments.
- a) Both A and R are true, and R is the correct explanation of A.
- b) Both A and R are true, but R is not the correct explanation of A.
- c) A is true, but R is false.
- d) Both A and R are false.
Answer: a.
Question 88: Assertion (A): Red muscle fibres can perform sustained work for a long period without fatigue. Reason (R): Red muscle fibres depend largely on anaerobic glycolysis for ATP production.
- a) Both A and R are true, and R is the correct explanation of A.
- b) Both A and R are true, but R is not the correct explanation of A.
- c) A is true, but R is false.
- d) A is false, but R is true.
Answer: c.
Question 89: Which of the following statements about visceral muscles is INCORRECT?
- a) They do not exhibit any striation.
- b) Their activities are not under the voluntary control of the nervous system.
- c) They assist in the transportation of food through the digestive tract.
- d) They are structurally composed of cylindrical, multinucleated cells.
Answer: d.
Question 90: Match the following columns and select the correct option. Column I (Bone) - Column II (Number). P) Cranial bones - i) 14. Q) Facial bones - ii) 12 pairs. R) Ribs - iii) 8. S) Vertebrae - iv) 26.
- a) P-iii, Q-i, R-ii, S-iv.
- b) P-i, Q-iii, R-iv, S-ii.
- c) P-iii, Q-i, R-iv, S-ii.
- d) P-i, Q-ii, R-iii, S-iv.
Answer: a.
Question 91: Which of the following best describes the structural unit of a skeletal muscle?
- a) Sarcomere.
- b) Muscle fibre.
- c) Fascicle.
- d) Myofibril.
Answer: b.
Question 92: The masking of active sites on actin for myosin is mediated by which complex in the resting state?
- a) Troponin-Tropomyosin complex.
- b) Heavy meromyosin.
- c) Calcium-calmodulin complex.
- d) Calsequestrin.
Answer: a.
Question 93: During a maximum muscle contraction, which of the following bands may completely disappear?
- a) A-band.
- b) Z-line.
- c) I-band.
- d) M-line.
Answer: c.
Question 94: Identify the correct sequence of events in muscle contraction: 1) Release of Calcium ions 2) Neural signal at NMJ 3) Binding of ATP 4) Cross-bridge formation.
- a) 2, 1, 4, 3.
- b) 1, 2, 3, 4.
- c) 2, 4, 1, 3.
- d) 2, 3, 1, 4.
Answer: a.
Question 95: Which pair of bones forms the ball and socket joint of the pelvic girdle?
- a) Humerus and Scapula.
- b) Femur and Acetabulum of Coxal bone.
- c) Radius and Ulna.
- d) Femur and Tibia.
Answer: b.
Question 96: Assertion (A): The 11th and 12th pairs of ribs are called floating ribs. Reason (R): They are connected ventrally to the sternum by hyaline cartilage.
- a) Both A and R are true, and R is the correct explanation of A.
- b) Both A and R are true, but R is not the correct explanation of A.
- c) A is true, but R is false.
- d) Both A and R are false.
Answer: c.
Question 97: Which of the following is an example of an age-related bone disorder?
- a) Muscular dystrophy.
- b) Tetany.
- c) Osteoporosis.
- d) Myasthenia gravis.
Answer: c.
Question 98: The acromion process is classically associated with the articulation of the:
- a) Scapula and humerus.
- b) Clavicle and sternum.
- c) Scapula and clavicle.
- d) Ilium and pubis.
Answer: c.
Question 99: During the recovery phase of muscle contraction, calcium ions are pumped back to the sarcoplasmic cisternae. This process requires:
- a) ATP.
- b) Facilitated diffusion.
- c) Osmosis.
- d) Simple diffusion.
Answer: a.
Question 100: Which of the following combinations perfectly matches the joint type with its location?
- a) Pivot joint - between carpal and metacarpal of thumb.
- b) Saddle joint - between atlas and axis.
- c) Gliding joint - between the carpals.
- d) Fibrous joint - pubic symphysis.
Answer: c.


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