Question 1: Which of the following plasma proteins is primarily responsible for maintaining the osmotic balance of the blood?
- a) Fibrinogen.
- b) Globulin.
- c) Albumin.
- d) Prothrombin.
Answer: c.
Question 2: In a healthy adult human, what is the average percentage of plasma in the blood and the water content in that plasma, respectively?
- a) 45 percent and 90-92 percent.
- b) 55 percent and 90-92 percent.
- c) 55 percent and 6-8 percent.
- d) 45 percent and 6-8 percent.
Answer: b.
Question 3: Identify the agranulocyte that acts as a highly active phagocytic cell in the blood.
- a) Neutrophil.
- b) Eosinophil.
- c) Monocyte.
- d) Basophil.
Answer: c.
Question 4: Which of the following leucocytes secretes histamine, serotonin, and heparin and is involved in inflammatory reactions?
- a) Basophils.
- b) Eosinophils.
- c) Neutrophils.
- d) Lymphocytes.
Answer: a.
Question 5: What is the average lifespan of a human erythrocyte, and where is it destroyed after this period?
- a) 120 days, Liver.
- b) 120 days, Spleen.
- c) 100 days, Bone marrow.
- d) 100 days, Spleen.
Answer: b.
Question 6: Serum can be defined as plasma minus which of the following components?
- a) Calcium ions.
- b) Formed elements.
- c) Clotting factors.
- d) Globulins.
Answer: c.
Question 7: A healthy adult has an average of how many grams of haemoglobin in every 100 ml of blood?
- a) 10-12 gms.
- b) 12-16 gms.
- c) 16-20 gms.
- d) 8-10 gms.
Answer: b.
Question 8: Megakaryocytes, which produce blood platelets, are specialized cells found in the:
- a) Spleen.
- b) Lymph nodes.
- c) Bone marrow.
- d) Liver.
Answer: c.
Question 9: Which of the following types of WBCs is most abundant in human blood?
- a) Lymphocytes.
- b) Monocytes.
- c) Eosinophils.
- d) Neutrophils.
Answer: d.
Question 10: Erythroblastosis foetalis can occur when:
- a) Mother is Rh positive and foetus is Rh negative.
- b) Mother is Rh negative and foetus is Rh positive.
- c) Both mother and foetus are Rh negative.
- d) Both mother and foetus are Rh positive.
Answer: b.
Question 11: A person with blood group AB is considered a universal recipient because their plasma contains:
- a) Both anti-A and anti-B antibodies.
- b) No natural antibodies against A and B antigens.
- c) Neither A nor B antigens on RBCs.
- d) Only anti-A antibodies.
Answer: b.
Question 12: The ABO blood grouping is primarily based on the presence or absence of two surface antigens on the:
- a) Leucocytes.
- b) Plasma.
- c) Platelets.
- d) Erythrocytes.
Answer: d.
Question 13: In the blood coagulation cascade, which enzyme catalyzes the conversion of inactive fibrinogen into fibrin?
- a) Thrombokinase.
- b) Prothrombin.
- c) Thrombin.
- d) Heparin.
Answer: c.
Question 14: Which specific metal ion plays an indispensable role in the blood clotting process?
- a) Sodium ion.
- b) Potassium ion.
- c) Calcium ion.
- d) Magnesium ion.
Answer: c.
Question 15: Thrombokinase, required to convert prothrombin to thrombin, is an enzyme complex formed by a series of linked enzymic reactions called a:
- a) Glycolytic pathway.
- b) Cascade process.
- c) Feedback loop.
- d) Bohr effect.
Answer: b.
Question 16: Interstitial fluid or tissue fluid has the same mineral distribution as that of:
- a) Cytoplasm.
- b) Plasma.
- c) Pure water.
- d) Whole blood.
Answer: b.
Question 17: Fats are absorbed through the lymph in specialized lymphatic vessels present in the intestinal villi known as:
- a) Lacteals.
- b) Capillaries.
- c) Venules.
- d) Sinuses.
Answer: a.
Question 18: Annelids and chordates share which of the following circulatory characteristics?
- a) Open circulatory system.
- b) Closed circulatory system.
- c) Incomplete double circulation.
- d) Haemocoel circulation.
Answer: b.
Question 19: Which of the following groups of animals possesses a three-chambered heart with two atria and a single ventricle?
- a) Fishes and amphibians.
- b) Amphibians and reptiles (except crocodiles).
- c) Birds and mammals.
- d) Crocodiles and birds.
Answer: b.
Question 20: In incomplete double circulation seen in amphibians, mixing of oxygenated and deoxygenated blood occurs in the:
- a) Left atrium.
- b) Right atrium.
- c) Single ventricle.
- d) Conus arteriosus.
Answer: c.
Question 21: The human heart is situated in the thoracic cavity, in between the two lungs, and is slightly tilted towards the:
- a) Right side.
- b) Left side.
- c) Posterior side.
- d) Anterior side.
Answer: b.
Question 22: The protective double-walled membranous bag enclosing the human heart is called the:
- a) Pleura.
- b) Pericardium.
- c) Peritoneum.
- d) Meninges.
Answer: b.
Question 23: The opening between the right atrium and the right ventricle is guarded by a valve formed of three muscular flaps called the:
- a) Bicuspid valve.
- b) Mitral valve.
- c) Tricuspid valve.
- d) Semilunar valve.
Answer: c.
Question 24: The bicuspid valve, also known as the mitral valve, regulates the flow of blood from the:
- a) Right atrium to right ventricle.
- b) Left atrium to left ventricle.
- c) Right ventricle to pulmonary artery.
- d) Left ventricle to aorta.
Answer: b.
Question 25: A specialized cardiac musculature distributed in the heart that possesses the highest auto-excitability and acts as the pacemaker is the:
- a) Atrio-ventricular node (AVN).
- b) Bundle of His.
- c) Purkinje fibres.
- d) Sino-atrial node (SAN).
Answer: d.
Question 26: The SAN generates an action potential that spreads to both atria, causing them to undergo simultaneous contraction known as:
- a) Ventricular systole.
- b) Atrial diastole.
- c) Atrial systole.
- d) Joint diastole.
Answer: c.
Question 27: What is the approximate duration of one complete cardiac cycle in a healthy resting human?
- a) 0.1 seconds.
- b) 0.3 seconds.
- c) 0.4 seconds.
- d) 0.8 seconds.
Answer: d.
Question 28: During a cardiac cycle, the volume of blood pumped out by each ventricle is approximately 70 mL, which is termed the:
- a) Cardiac output.
- b) End-diastolic volume.
- c) Stroke volume.
- d) Tidal volume.
Answer: c.
Question 29: Cardiac output can be defined and calculated as the product of:
- a) Stroke volume and heart rate.
- b) Blood pressure and heart rate.
- c) Stroke volume and respiratory rate.
- d) End-systolic volume and stroke volume.
Answer: a.
Question 30: The first heart sound (lub) is associated with the closure of the:
- a) Semilunar valves.
- b) Tricuspid and bicuspid valves.
- c) Foramen ovale.
- d) Eustachian valves.
Answer: b.
Question 31: The second heart sound (dub) is primarily associated with the closure of the:
- a) Tricuspid valve.
- b) Bicuspid valve.
- c) Semilunar valves.
- d) Thebesian valve.
Answer: c.
Question 32: In a standard ECG, the P-wave represents the electrical excitation or depolarisation of the:
- a) Ventricles.
- b) Atria.
- c) Bundle of His.
- d) Purkinje fibres.
Answer: b.
Question 33: In an electrocardiogram (ECG), the QRS complex specifically represents the:
- a) Repolarisation of ventricles.
- b) Depolarisation of atria.
- c) Depolarisation of ventricles.
- d) Repolarisation of atria.
Answer: c.
Question 34: The T-wave in a standard ECG signifies the return of the ventricles from excited to normal state, a process known as:
- a) Repolarisation.
- b) Depolarisation.
- c) Hyperpolarisation.
- d) Action potential generation.
Answer: a.
Question 35: The end of the T-wave in an ECG visually marks the end of:
- a) Atrial systole.
- b) Ventricular diastole.
- c) Ventricular systole.
- d) Joint diastole.
Answer: c.
Question 36: Double circulation implies that the blood passes through the heart twice during one complete cycle. It includes:
- a) Renal circulation and portal circulation.
- b) Pulmonary circulation and systemic circulation.
- c) Open circulation and closed circulation.
- d) Coronary circulation and lymphatic circulation.
Answer: b.
Question 37: Pulmonary circulation begins with the pumping of deoxygenated blood by the:
- a) Left atrium.
- b) Left ventricle.
- c) Right atrium.
- d) Right ventricle.
Answer: d.
Question 38: The systemic circulation provides nutrients, oxygen, and other essential substances to tissues and takes away carbon dioxide via the:
- a) Pulmonary vein.
- b) Pulmonary artery.
- c) Aorta.
- d) Vena cava.
Answer: c.
Question 39: A unique vascular connection exists between the digestive tract and liver, which carries blood from the intestine to the liver before it is delivered to the systemic circulation. It is called:
- a) Renal portal system.
- b) Hepatic portal system.
- c) Hypophyseal portal system.
- d) Coronary system.
Answer: b.
Question 40: Normal activities of the human heart are regulated intrinsically, meaning it is:
- a) Neurogenic.
- b) Myogenic.
- c) Regulated entirely by the medulla oblongata.
- d) Regulated by the cerebral cortex.
Answer: b.
Question 41: A special neural centre that can moderate the cardiac function through the autonomic nervous system (ANS) is located in the:
- a) Cerebrum.
- b) Hypothalamus.
- c) Medulla oblongata.
- d) Cerebellum.
Answer: c.
Question 42: Parasympathetic neural signals affect the heart by:
- a) Increasing the rate of heartbeat and cardiac output.
- b) Decreasing the rate of heartbeat and speed of conduction of action potential.
- c) Increasing the strength of ventricular contraction.
- d) Having no significant effect on cardiac output.
Answer: b.
Question 43: Adrenal medullary hormones can profoundly influence cardiac activity by:
- a) Decreasing heart rate.
- b) Increasing cardiac output.
- c) Inhibiting the SA node.
- d) Promoting vasodilation in the digestive system.
Answer: b.
Question 44: High blood pressure (Hypertension) is a clinical term for blood pressure that is consistently higher than:
- a) 120/80 mm Hg.
- b) 140/90 mm Hg.
- c) 100/60 mm Hg.
- d) 110/70 mm Hg.
Answer: b.
Question 45: In the measurement 120/80 mm Hg, the number 120 represents:
- a) Diastolic pressure.
- b) Venous pressure.
- c) Systolic or pumping pressure.
- d) Pulse pressure.
Answer: c.
Question 46: Coronary Artery Disease (CAD), characterized by deposits of calcium, fat, cholesterol, and fibrous tissue that make the lumen of arteries narrower, is also referred to as:
- a) Atherosclerosis.
- b) Arteriosclerosis.
- c) Angina pectoris.
- d) Heart failure.
Answer: a.
Question 47: A symptom of acute chest pain appears when no enough oxygen is reaching the heart muscle. This condition is termed as:
- a) Myocardial infarction.
- b) Heart block.
- c) Angina pectoris.
- d) Cardiac arrest.
Answer: c.
Question 48: The state of heart when it is not pumping blood effectively enough to meet the needs of the body is called:
- a) Heart failure.
- b) Heart attack.
- c) Cardiac arrest.
- d) Angina.
Answer: a.
Question 49: Heart failure is sometimes also called congestive heart failure because a major symptom of this disease is congestion of the:
- a) Liver.
- b) Kidneys.
- c) Lungs.
- d) Brain.
Answer: c.
Question 50: Cardiac arrest refers specifically to the condition where:
- a) The heart muscle is suddenly damaged.
- b) The heart stops beating completely.
- c) The arteries are blocked by plaques.
- d) Blood pressure remains consistently high.
Answer: b.
Question 51: The fluid that leaves the capillaries to form tissue fluid is nearly identical to plasma, EXCEPT that it lacks:
- a) Glucose and amino acids.
- b) Water and electrolytes.
- c) Larger proteins and most formed elements.
- d) Carbon dioxide and urea.
Answer: c.
Question 52: Which formed elements lack a nucleus in most mammals and possess a biconcave shape?
- a) Eosinophils.
- b) Lymphocytes.
- c) Erythrocytes.
- d) Monocytes.
Answer: c.
Question 53: If the stroke volume of an individual is 70 mL and their heart rate is 72 beats per minute, the cardiac output is approximately:
- a) 4000 mL.
- b) 5000 mL.
- c) 6000 mL.
- d) 7000 mL.
Answer: b.
Question 54: The bundle of His is a network of specialized muscle fibres found in the:
- a) Wall of the atria.
- b) Wall of the right ventricle only.
- c) Inter-ventricular septum extending to ventricular walls.
- d) Inter-atrial septum.
Answer: c.
Question 55: Which node is responsible for generating the maximum number of action potentials (70-75 per minute) in the heart?
- a) Sino-atrial node (SAN).
- b) Atrio-ventricular node (AVN).
- c) Bundle of His.
- d) Purkinje fibres.
Answer: a.
Question 56: The sequence of cyclical events taking place in the heart from the beginning of one heartbeat to the beginning of the next is called:
- a) Systemic circulation.
- b) Cardiac cycle.
- c) Double circulation.
- d) Stroke volume cycle.
Answer: b.
Question 57: During the initial stage of the cardiac cycle (joint diastole), the tricuspid and bicuspid valves are:
- a) Completely closed.
- b) Partially closed.
- c) Open.
- d) Fibrillating.
Answer: c.
Question 58: Atrial systole accounts for an increase in the flow of blood into the ventricles by approximately:
- a) 10 percent.
- b) 20 percent.
- c) 30 percent.
- d) 50 percent.
Answer: c.
Question 59: When ventricular pressure increases during ventricular systole, it first causes the closure of the:
- a) Semilunar valves.
- b) Tricuspid and bicuspid valves.
- c) Sino-atrial node.
- d) Pulmonary trunk.
Answer: b.
Question 60: The normal healthy resting heart rate in adult humans is around:
- a) 60 - 65 beats per minute.
- b) 70 - 75 beats per minute.
- c) 80 - 85 beats per minute.
- d) 90 - 100 beats per minute.
Answer: b.
Question 61: What clinical technique is routinely used to record the electrical activity of the heart over a complete cardiac cycle?
- a) Electroencephalography (EEG).
- b) Echocardiography (ECHO).
- c) Electrocardiography (ECG).
- d) Magnetic Resonance Imaging (MRI).
Answer: c.
Question 62: To obtain a standard ECG, a patient is typically connected to the machine using how many electrical leads?
- a) Two (one to each wrist).
- b) Three (one to each wrist and to the left ankle).
- c) Four (one to each limb).
- d) Six (on the chest only).
Answer: b.
Question 63: By counting the number of QRS complexes that occur in a given time period on an ECG, one can determine the:
- a) Stroke volume of the patient.
- b) Heart beat rate of an individual.
- c) Cardiac output of the patient.
- d) Blood pressure of the patient.
Answer: b.
Question 64: Annelids possess a closed circulatory system. This implies that their blood is:
- a) Pumped into open sinuses.
- b) Circulated through a closed network of blood vessels.
- c) Directed primarily towards the gills for oxygenation.
- d) Identical in composition to interstitial fluid.
Answer: b.
Question 65: Single circulation, where the heart pumps out only deoxygenated blood that is oxygenated by gills, is characteristic of:
- a) Fishes.
- b) Amphibians.
- c) Reptiles.
- d) Birds.
Answer: a.
Question 66: Crocodiles, unlike most other reptiles, possess a heart with:
- a) Two chambers.
- b) Three chambers.
- c) Four chambers.
- d) Five chambers.
Answer: c.
Question 67: In humans, the pulmonary artery carries deoxygenated blood from the right ventricle to the:
- a) Left atrium.
- b) Body tissues.
- c) Lungs.
- d) Liver.
Answer: c.
Question 68: The thick fibrous tissue separating the atrium and the ventricle of the same side is called the:
- a) Inter-atrial septum.
- b) Inter-ventricular septum.
- c) Atrio-ventricular septum.
- d) Chordae tendineae.
Answer: c.
Question 69: The walls of the ventricles are much thicker than those of the atria because:
- a) They have to generate greater pressure to pump blood to distant organs.
- b) They receive blood at a very low pressure.
- c) They hold a much larger volume of blood permanently.
- d) They are heavily innervated by parasympathetic nerves.
Answer: a.
Question 70: Chordae tendineae are special fibrous cords found within the heart that connect the:
- a) Atria to the ventricles directly.
- b) Semilunar valves to the aorta.
- c) Ventricular walls to the SAN.
- d) Tricuspid and bicuspid valve flaps to papillary muscles.
Answer: d.
Question 71: The systemic vein that returns deoxygenated blood from the upper body parts to the right atrium is the:
- a) Pulmonary vein.
- b) Superior vena cava.
- c) Inferior vena cava.
- d) Hepatic vein.
Answer: b.
Question 72: A small mass of specialized nodal tissue located in the lower left corner of the right atrium close to the atrio-ventricular septum is called:
- a) Sino-atrial node (SAN).
- b) Atrio-ventricular node (AVN).
- c) Purkinje fibres.
- d) Papillary muscle.
Answer: b.
Question 73: The right and left bundles derived from the AV bundle give rise to minute fibres distributed throughout the ventricular musculature called:
- a) Nerve fibres.
- b) Muscle spindles.
- c) Purkinje fibres.
- d) Collagen fibres.
Answer: c.
Question 74: During joint diastole, blood from the pulmonary veins and vena cava flows into the left and right ventricles respectively through the open:
- a) Semilunar valves.
- b) Eustachian valves.
- c) Atrio-ventricular valves.
- d) Thebesian valves.
Answer: c.
Question 75: Oxygenated blood from the lungs is carried to the left atrium by the:
- a) Pulmonary artery.
- b) Pulmonary veins.
- c) Vena cava.
- d) Aorta.
Answer: b.
Question 76: Which node sets the pace of the activities of the human heart?
- a) AV node.
- b) SA node.
- c) Bundle of His.
- d) Purkinje fibres.
Answer: b.
Question 77: The number of formed elements per cubic millimeter of blood normally is highest for:
- a) Platelets.
- b) Erythrocytes.
- c) Neutrophils.
- d) Lymphocytes.
Answer: b.
Question 78: A reduction in the number of blood platelets can lead to:
- a) Anaemia.
- b) Clotting disorders and excessive blood loss.
- c) Immune deficiency.
- d) Increased phagocytosis.
Answer: b.
Question 79: Which type of white blood cells resists infections and is associated with allergic reactions?
- a) Basophils.
- b) Monocytes.
- c) Eosinophils.
- d) Neutrophils.
Answer: c.
Question 80: 'B' and 'T' forms are the two major types of which of the following agranulocytes responsible for immune responses?
- a) Monocytes.
- b) Lymphocytes.
- c) Neutrophils.
- d) Basophils.
Answer: b.
Question 81: An Rh-ve individual receiving Rh+ve blood for the first time will:
- a) Exhibit immediate severe agglutination.
- b) Form specific antibodies against the Rh antigens.
- c) Accept the blood without any future immune consequences.
- d) Convert their own blood type to Rh+ve.
Answer: b.
Question 82: To prevent erythroblastosis foetalis in a subsequent pregnancy, an Rh-negative mother is administered:
- a) Anti-Rh antibodies immediately after the delivery of her first Rh+ve child.
- b) Rh antigens during the pregnancy.
- c) Anti-A and anti-B antibodies before conception.
- d) Immunosuppressants throughout the pregnancy.
Answer: a.
Question 83: Which mineral represents the major cation in extracellular fluids like plasma and interstitial fluid?
- a) Potassium (K+).
- b) Magnesium (Mg++).
- c) Sodium (Na+).
- d) Calcium (Ca++).
Answer: c.
Question 84: Lymphatic system ultimately drains the collected tissue fluid back into the:
- a) Major arteries.
- b) Interstitial spaces.
- c) Major veins.
- d) Kidneys.
Answer: c.
Question 85: The opening of the left ventricle into the aorta is provided with:
- a) Bicuspid valves.
- b) Tricuspid valves.
- c) Semilunar valves.
- d) Mitral valves.
Answer: c.
Question 86: The second heart sound 'dub' occurs when the ventricular pressure falls causing the closure of semilunar valves to prevent:
- a) Forward flow of blood into the aorta.
- b) Backflow of blood into the ventricles.
- c) Backflow of blood into the atria.
- d) Forward flow of blood into the pulmonary artery.
Answer: b.
Question 87: The T-wave represents the repolarisation of the ventricles. A flat T-wave on an ECG might clinically indicate:
- a) Atrial hypertrophy.
- b) Sufficient oxygen supply to the heart muscle.
- c) Insufficient oxygen supply to the heart muscle (ischaemia).
- d) Increased stroke volume.
Answer: c.
Question 88: Systemic circulation is highly significant because it ensures that:
- a) Deoxygenated blood is converted to oxygenated blood.
- b) Tissues receive oxygen and nutrients while wastes are carried away.
- c) The liver receives direct oxygenated blood from the gut.
- d) The lungs are supplied with nutrients.
Answer: b.
Question 89: Which component of the autonomic nervous system increases the heart rate and the strength of ventricular contraction?
- a) Parasympathetic neural signals.
- b) Sympathetic neural signals.
- c) Vagus nerve.
- d) Somatic motor nerves.
Answer: b.
Question 90: Sustained hypertension can lead to complications and primarily affects vital organs such as:
- a) Skin and bones.
- b) Brain and kidneys.
- c) Lungs and liver.
- d) Stomach and intestines.
Answer: b.
Question 91: Angina pectoris can occur in men and women of any age but it is most common among the:
- a) Infants and teenagers.
- b) Young adults.
- c) Middle-aged and elderly.
- d) Neonates.
Answer: c.
Question 92: The normal physiological function of the coronary circulation is to:
- a) Supply oxygenated blood to the liver.
- b) Supply oxygenated blood exclusively to the heart musculature.
- c) Drain deoxygenated blood from the lungs.
- d) Facilitate absorption of fats in the intestine.
Answer: b.
Question 93: Match the blood cells with their relative abundance in human blood: Neutrophils.
- a) 60-65 percent.
- b) 20-25 percent.
- c) 6-8 percent.
- d) 0.5-1 percent.
Answer: a.
Question 94: Lymph lacks which of the following crucial blood components?
- a) Water.
- b) Lymphocytes.
- c) Erythrocytes and larger proteins.
- d) Minerals like Na+ and Cl-.
Answer: c.
Question 95: Complete separation of oxygenated and deoxygenated blood occurs strictly in:
- a) Fishes and amphibians.
- b) Reptiles and amphibians.
- c) Birds and mammals.
- d) Fishes and reptiles.
Answer: c.
Question 96: In a normal electrocardiogram, which electrical event is invisible because it is masked by the QRS complex?
- a) Atrial depolarisation.
- b) Ventricular depolarisation.
- c) Atrial repolarisation.
- d) Ventricular repolarisation.
Answer: c.
Question 97: Myocardial infarction (heart attack) refers to the condition where:
- a) Heart rhythm becomes irregular.
- b) Heart muscle is suddenly damaged by an inadequate blood supply.
- c) The heart valves fail to close properly.
- d) The SA node stops generating action potentials completely.
Answer: b.
Question 98: A person has a blood type with no antigens on the RBC surface but both anti-A and anti-B antibodies in the plasma. The blood type is:
- a) Group A.
- b) Group B.
- c) Group AB.
- d) Group O.
Answer: d.
Question 99: If the parasympathetic nerve supplying the heart is severed, what will be the immediate physiological effect?
- a) The heart will stop beating completely.
- b) The heart rate will decrease.
- c) The heart rate will increase.
- d) Cardiac output will fall to zero.
Answer: c.
Question 100: Which of the following pathways correctly describes the flow of oxygenated blood in double circulation?
- a) Lungs -> Pulmonary vein -> Left atrium -> Left ventricle -> Aorta -> Body tissues.
- b) Body tissues -> Vena cava -> Right atrium -> Right ventricle -> Pulmonary artery -> Lungs.
- c) Lungs -> Pulmonary artery -> Left atrium -> Left ventricle -> Aorta -> Body tissues.
- d) Body tissues -> Vena cava -> Left atrium -> Left ventricle -> Aorta -> Lungs.
Answer: a.


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